Palazzo Marchesini was built in the 15th century. It was a building located on Via di Mezzo di San Martino, so called because it crossed the possessions of the convent of San Martino, and was formerly a Roman decumanus (thus one of the most important streets in the city).

Like all noble buildings of the time, the palace saw stables on the ground floor, the noble apartment on the second floor, and rooms reserved for staff on the second. The facade featured a wooden portico, which is no longer present today. The noble apartment on the second floor still has a large hall with a wooden ceiling and a frescoed fascia depicting the coming of Clement VII for the coronation of Charles V as emperor. Historian Giuseppe Guidicini (b. 08/29/1763, d. 01/25/1837) writes, "In the hall evvi a frieze, representing the cavalcade made in Bologna in 1530 for the coronation of Emperor Charles V, which differs greatly from what Bruciasorci and Hongherberg hint at in their prints." (https://www.originebologna.com/strade/via-di-mezzo-di-san-martino/n-2750/)

The building was owned by several families, and, in Bolognese usage, changed its name with the change of the family that owned it. Formerly inhabited by the Salicetti family, very prominent in Bologna, in 1532 it passed to the Bettini Family (which changed its name several times over time: Fabbri, Fabretti, Bonavolta). When Giovanni Antonio Bonavolta died, the building remained the property of his three daughters, two of whom had taken vows. Thus it was that the church claimed ownership, the nuns having taken a vow of renunciation (1661). In 1662 the church gave the building under emphyteutical lease to the Budrioli family, another well-known family in Bologna, and in 1746 Alberto Budrioli appointed Senator Carlo Grassi as his successor in the emphyteutical lease. When the emphyteutic lease ended, the building returned to the church. In 1772 it was sold to Giacomo Bonazzi, and later to Giacomo Panzarasa, who remodeled the facade by knocking down the old wooden portico placed on the street and giving the building an appearance similar to the present one.

Later the building passed to the Marchesini family, and in 1933 it was taken over by the Guidicini family, which, for undocumented reasons, did not give it its own name. And it is from this family that the current ownership of the apartment in which the B&B is located descends.

Along the wooden staircase leading to the apartment, some fine high reliefs can be seen. Also visible inside the B & B are a coat of arms and a ceramic high relief depicting 11 young people with garlands of fruit and flowers.